PLASMA PROTEINS

 

INTRODUCTION: Total blood volume is about 4.5 to 5 liters in adult human being. If blood is mixed with an anticoagulant and centrifuged, the cell components which iclude Red blood cells (RBC) and white blood cells (WBC) are precipitated. The supernatant is called plasma. About 55-60% of blood is made up of plasma. If blood is withdrawn without anticoagulant and allowed to clot, after about 2 hours liquid portion is separated from the clot. This defibrinated plasma is called serum, which lacks coagulation factors including prothrombin and fibrinogen.

PROTEINS IN BLOOD: Total protein content of normal plasma is 6 to 8 g/100 ml. The plasma proteins consist of albumin, which is about 3.5 to 5 g/dl, globulins which make up 2.5-3.5 g/dl and fibrinogen making it to about 200-400 mg/dl. Almost all plasma proteins, except immunoglobulins are synthesized in liver. Plasma proteins are generally synthesised on membrane-bound polyribosomes. Most plasma proteins are glycoproteins.

RELATED;

1. BLOOD AND IT’S COMPONENTS

2. PROTEINS

3. IMMUNOGLOBULINS

REFERENCES