CHRONIC INFLAMMATION

 

Introduction: Chronic inflammatory happens when there is a reaction over a prolonged period of time, that is to say, months to years, in which active inflammation plus a healing process occur at a time. This usually proceeded by acute inflammation when the causative agent is not removed and is characterized by the following changes; 

1) Diminished polymorphs cells and presences of macrophages, (epitheliod, and giant cells), plasma cells, and lymphocytes, in addition to vascular budding and formation of new capillaries also known as angiogenesis.  LYMPHOCYTES

In the same case, there is proliferation of fibroblast and fibrosis which is an attempt of healing.  WOUNDHEALING  

2) Cells in the chronic inflammatory process tend to produce substances that add new tissue, such as collagen and new blood vessels, many of these changes also represent the repair process, and there is a blurry continuum between chronic inflammation and the whole repair process.  In general, chronic inflammation is characterized by tissue destruction and attempts at repair, all happening at a time. Comparison between Acute and Chronic Inflammation: Acute inflammation occurs during a short period of time, days or weeks, in the presence of all cardinal signs of inflammation and infiltration of inflammatory cells, mainly neutrophil. While, chronic inflammation occurs in a long period of time, months or years, and is infiltrated with lymphocytes, plasma cells and macrophages associated with formation of fibrous tissue in the periphery of the inflamed tissue.

RELATED;

1.  THE PROCESS OF INFLATION  

2.  CELLULAR EVENTS DURING INFLAMMATION  

3.  PATHOLOGY

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