Pharmacologic Class: Antacid
ACTIONS AND USES: Aluminum hydroxide is an inorganic agent used alone or in combination with other antacids. Combining aluminum compounds with magnesium, increases their effectiveness and reduces the potential for constipation. Unlike calcium-based antacids that can be absorbed and cause systemic effects, aluminum compounds are minimally absorbed. Their primary action is to neutralize stomach acid by raising the pH of the stomach contents.
Unlike H2-receptor antagonists and PPIs, aluminum antacids do not reduce the volume of acid secretion. They are most effectively used in combination with other antiulcer drugs for the symptomatic relief of heartburn due to PUD or GERD.
ADMINISTRATION ALERTS: Administer aluminum antacids at least 2 hours before or after other drugs because absorption could be affected. Pregnancy category C
ADVERSE EFFECTS: When taken regularly or in high doses, aluminum antacids cause constipation.
At high doses, aluminum products bind with phosphate in the GI tract and long-term use can result in phosphate depletion. Those at risk include those who are malnourished, alcoholics, and those with renal disease.
Contraindications: This drug should not be used in patients with suspected bowel obstruction.
INTERACTIONS: Drug–Drug: Aluminum compounds should not be taken at the same time as
other medications, because they may interfere with absorption.
RELATED;
2. CONSTIPATION
3. HISTAMINE 2 RECEPTOR BLOCKERS
4. DIARRHEA
5. PHARMACOLOGY AND THERAOEUTICS
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