Sunday, August 15, 2021

WOUND HEALING BY SECONDARY INTENTION

 

INTRODUCTION:  Wound Healing by Second Intention.  This is also known as Secondary Union.  This type of healing occurs when injuries result in more extensive loss of tissues, such as with infarction, inflammatory ulceration, and large surface wounds. In these situations, due to the large tissue defects, repair by regeneration is minimal and the defect is filled with granulation tissue.  
Second intention healing differ from first intention healing in several ways as described below;  First the greater injury induce a more intense inflammatory response. Secondly, much more granulation tissue is formed, and thirdly wounds that are repaired by second intention healing undergo a phenomenon known as "wound contraction" whereby specialized granulation tissue fibroblasts called myofibroblasts contract and dramatically reduce the size of the wound.

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