INTRODUCTION: Disseminated Intravascular Coagulation (DIC) is one of the primary bleeding disorders and the leading cause of death from highly stimulating antigens.
Disseminated = All over
Intravascular = within the circulation
Coagulation = Platelet plug formation.
PATHOPHYSIOLOGY: In this condition the trigger for immune response is so intense that the body is oversensitised, leading to activation of the coagulation cascade and overconsumption of clotting factors. This is a condition where the clotting factors in blood are over activated, which lead to formation of micro emboli throughout the circulation, triggering multi-organ dysfunction.
CAUSES OF DIC: These are the possible causes of DIC:
1) Amniotic fluid embolism as a result of obstetric procedures.
2) Air embolism especially during insertion of intravenous lines.
3) Invasion by microbes especially Hemorrhagic fever viruses, highly virulent bacteria.
4) Simultaneous body tissue injury.
Complications as a result of DIC: 1) Depletion of clotting factors leading to coagulopathies.
2) Occlusion of blood microcirculation.
RELATED;
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