Pharmacologic Class: Bone resorption inhibitor
ACTIONS AND USES: Calcitriol is the active form of vitamin D. It promotes the intestinal absorption of calcium and elevates serum levels of calcium. This medication is indicated for patients with chronic kidney disease or hypoparathyroidism. Calcitriol reduces bone resorption and is used off-label to treat rickets. The effectiveness of calcitriol depends on an adequate amount of calcium; therefore, it is usually prescribed in combination with calcium supplements. It is available as oral tablets and solutions and by the IV route.
ADMINISTRATION ALERTS: Protect capsules from light and heat. Pregnancy category C.
ADVERSE EFFECTS: Vitamin D therapy may cause symptoms of hypercalcemia. These include palpitations, anorexia, nausea, vomiting, blurred vision, photophobia, constipation abdominal cramps, metallic taste, headache, weakness, dry mouth, thirst, increased urination, and muscle or bone pain.
CONTRAINDICATIONS: This drug should not be given to patients with hypercalcemia or with evidence of vitamin D toxicity.
INTERACTIONS:
Drug–Drug: Thiazide diuretics may enhance the effects of vitamin D, causing hypercalcemia. Too much vitamin D may cause dysrhythmias in patients who are receiving digoxin. Magnesium antacids or supplements should not be given concurrently due to the increased risk of hypermagnesemia.
RELATED;
1. VITAMIN A
2. CO-ENZYMES
3. VITAMIN C
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